Arknights
Hypergryph's Arknights is a tower defense RPG that goes to some very dark places in the genre. Natural disasters known as Catastrophes are always destroying the world of Terra. Originium is a mineral that powers civilization and gives people a disease called Oripathy, which is very stigmatized. You are the Doctor, an amnesiac strategist who runs Rhodes Island, a pharmaceutical company that is basically fighting a war on two fronts: treating the Infected and fighting the discrimination they face. The story doesn't hold back; it talks about war, medical ethics, and political corruption. It's like tower defense, but much more complicated. Every unit is an Operator with its own skills and classes. You need to plan ahead and time your moves to stop enemy waves, especially the radical Infected group called Reunion. The whole look is this rough tech-wear style that fits the dystopian setting perfectly.